• About ICOS Impianti

• Depyrogenation Oven

• Steam Sterilizing Autoclave

• Ethylene Oxide Sterilizing Autoclave

• Air + Steam Mixture Sterilizing Autoclave

• Superheated Water Sterilizing Autoclave

• Stopper Washer/Siliconizing/Drying

• Stopper Washer/Siliconizing/Sterilizing

• Equipment/Parts/Glassware Washer

• Tray Drying Oven

• Tank Cleaning Enclosure (Washing/Sterilizing/Drying)

About ICOS Impianti

ICOS Impianti Group is a leading company in the design, manufacture and supply of high-quality machinery for washing, sterilization and heat sterilization operating in the pharmaceutical, para-pharmaceutical, medical cosmetic and food services fields.  Honesty, transparency, innovation, commitment to safety and the environment: these are the results of a strong and recognized cultural identity, which has been handed down in ICOS for over 25 years.

The Life Sciences Division produces equipment for the washing, sterilization and drying for pharmaceutical products, equipment and components as well as machines for sterilization with steam, air+water, superheated water, or EO gas.
The products in this line are the perfect result of a strategic formula that calls for the implementation of advanced manufacturing methods, various control procedures and safe and reliable tests.

The entire range is manufactured according to pharmaceutical standards cGMP, GAMP, and FDA's 21CFR Parts 11, 210 and 211, using high-quality industrial components. High-quality finishing is ensured for both the process surfaces as well as for the areas of interface between sterile and non-sterile zones.

ICOS provides the client with technical support both during the manufacturing and testing phase of the machine, and furnishes complete documentation.

• Download PDF - ICOS Line Card

• Download PDF of ICOS General Presentation

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SD Series Depyrogenation Oven

    ICOS' Class 100 Static Air Depyrogenation Sterilizers rank with the most technologically advanced machines in the field today.  They are used for the sterilization and depyrogenation of heat-resistant materials such as bottles, vials, glass containers, metal containers, metal shelves and machine parts.  The SD series ranges in capacity from 309 Liters to 10,126 Liters

Characteristics of the Depyrogenation Oven:

• HEPA filtration of air - 99.99% efficiency
• PLC control of the system, including pressure and temperature
• Uniform Air distribution - particularly suited for differentiated loads
• Uniform Temperature on the product +/- 3ºC
• Hermetically sealed doors with unique gasket for the formation of a vacuum guarantees a perfect seal every cycle, and thereby avoiding contamination
• Mechanically designed to withstand temperatures of up to 300ºC
• Maximum temperature on the external surface will not exceed 40ºC
• Easy access to connections on the front (loading side) of the machine for validation
• All interior angles are rounded for easy cleaning
• Optional automatic loading and unloading systems
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant

Options of the Depyrogenation Oven:

• 3 types of doors - swing-out, sideways sliding, or vertical sliding
• Water based cooling system is standard - air-cooled system available
• Materials of construction are 304SS - 316SS is available on request

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Steam Sterilizing Autoclave

    ICOS is world renown in the pharmaceutical industry for their versatile line of autoclaves.  The AV/L and AV/S Series Steam Sterilizing Autoclaves are used for sterilizing steam resistant materials, such as vials, bottles, glass items, fabric materials, closed and open vessels, rubber articles, and machine parts.

    A wide range of steam sterilizing autoclaves are available, ranging from 85 Liters thru 3,840 Liters.  ICOS is also experienced at customizing autoclaves to customer specifications, including chamber size, performance, level of automation, etc, even so far as to combine Steam, superheated water, and air/steam mixture sterilization all into one unit!

Characteristics of the Steam Sterilizing Autoclaves from ICOS:

• Sterilizing chambers made of round or rectangular cross section and provided with a heat jacket;  the body is insulated with a ceramic material
• Doors may be either Swing Out (AV/L) or Vertical/Horizontal Sliding (AV/S)
• Discharge door is interfaceable with a sterile environment/isolator
• Optional automatic loading and unloading systems
• Machine body is made completely of 316L SS, with the exception of the external paneling and support frame
• Standard models come with a pneumatically pressurized gasket to ensure door tightness.  Optionally, the gasket can be made of an automatic pressure-sealing type to guarantee the tightness of the door in any condition
• The chamber's inside surface, the piping, and all parts in contact with the product are polished to a degree of roughness of ≤0.5μm
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant
• Laboratory Autoclaves available in either a horizontal or vertical format (85L and 150L)
• Capacity from 85L to 3,840L
• Download PDF AV/L & AV/S Steam Sterilizing Brochure
• Download PDF AV/L & AV/S Steam Sterilizing Brochure 2
• Download AV/L Technical Specs

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Ethylene Oxide Sterilizing Autoclave

    ICOS is world renown in the pharmaceutical industry for their versatile line of autoclaves.  The AGS and AGS-E Ethylene Oxide Sterilizing Autoclaves are used for sterilizing heat-sensitive products, such as plastic syringes, perfusion sets, and heat-sensitive rubber products.  The AGS Model uses a mixture of 10%EO to 90% Inert Gas while the AGS-E Models use a mixture with EO content over 10%

Characteristics of the Ethylene Oxide Sterilizing Autoclaves from ICOS:

• Sterilizing chambers made of rectangular cross section and completely surrounded with a heating jacket for rapid and even heating of the load;  body is of 304SS;  hydraulic system and steam generator of 316SS
• Doors are sealed with a pneumatically pressurized gasket;  the hermetic closure of autoclaves that use an explosive mixture is guaranteed by a pressure sealing device with automatic tie rods designed by ICOS, in compliance with international safety standards
• Load is moistened through an influx of low-pressure clean steam supplied by a steam generator
• EO gas is heated through the evaporator before being fed into the chamber
• Optimized for minimal energy consumption
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant
• Capacity from 450L to 30,400L
• Download PDF - ICOS Ethylene Oxide Sterilizing Autoclave

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Air+Steam Sterilizing Autoclave

    ICOS' has furthered their world class line of autoclaves thru the introduction of Air+Steam Sterilizing Autoclaves.  The AMS Series Autoclave is designed specifically with the pharmaceutical industry in mind.  They are used for the sterilization of liquids in containers such as bottles, pockets, bags, etc.

• Sterilization chamber has a round cross section, containing all the accessories for its use
• Body is insulated with ceramic material and externally lined with 304SS; body is made of 316L SS
• Chamber bottom fitted with guides for moving the product holding carts
• Optional automatic loading and unloading systems
• Standard models come with a pneumatically pressurized gasket to ensure door tightness.  Optionally, the gasket can be made of an automatic pressure-sealing type to guarantee the tightness of the door in any condition
• The chamber's inside surface, the piping, and all parts in contact with the product are polished to a degree of roughness of ≤0.5μm
• Capacities ranging from 1,234L to 23,150L

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Superheated Water Sterilizing Autoclave

    ICOS' has furthered their world class line of autoclaves thru the introduction of Superheated Water Sterilizing Autoclaves.  The ASS Series Autoclave is designed specifically with the pharmaceutical industry in mind.  They are used for the sterilization of liquids in containers such as bottles, pockets, bags, etc.

• Sterilization chamber has a round cross section, containing all the accessories for its use
• Body is insulated with ceramic material and externally lined with 304SS; body is made of 316L SS
• Chamber bottom fitted with guides for moving the product holding carts
• Optional automatic loading and unloading systems
• Standard models come with a pneumatically pressurized gasket to ensure door tightness.  Optionally, the gasket can be made of an automatic pressure-sealing type to guarantee the tightness of the door in any condition
• The chamber's inside surface, the piping, and all parts in contact with the product are polished to a degree of roughness of ≤0.5μm
• Capacities ranging from 1,234L to 23,150L

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Stopper Washer/Siliconizing/Drying

    ICOS' extensive experience with the treatment of stoppers for containers normally used in the pharmaceutical industry has lead them to produce the LT Series Stopper Washer (see LST Series below for Stopper Washer/Sterilizer)  This new range of ICOS equipment has several innovative features that exceed the industry's expectations. These Stopper Washers are designed for the complete treatment of sealing devices for pharmaceutical products, rubber and plastic stoppers, droppers, metal rings, etc.

    The LT machines is fully automated, and available in six sized to accommodate a wide variety of customer requirements.  The smallest unit (20L) can process roughly 6,000 of the 20mm standard stoppers, while the largest unit (240L) can process roughly 72,000 of the same.  The complete cycle time for the LT is approximately 2-2.5 hours

Characteristics of LT Series Stopper Washer

• Operating process consists of Washing, Rinsing, Siliconizing, Drying, and Cooling
• Distribution of load into separate baskets for better results;  by separating the stoppers, there is little or no mass weight to cause interlocking - thereby offering maximum surface exposure during each cycle phase
• Washing is done by simultaneously rotating the basket(s) and fluid-bed action from a recycling pump and spray nozzles.  The particles in suspension are removed
• Even siliconization of products guaranteed by recycling pump
• Drying is done through the use of HEPA filtered air
• Optional automatic loading and unloading systems
• Optional interface of unloading door to isolator
• All materials in contact with the process are 316SS
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant
• Capacity from 20L to 240L

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Stopper Washer/Siliconizing/Sterilizing

    ICOS' extensive experience with the treatment of stoppers for containers normally used in the pharmaceutical industry has lead them to produce the LT Series Stopper Washer (see LST Series below for Stopper Washer/Sterilizer)  This new range of ICOS equipment has several innovative features that exceed the industry's expectations.  These Stopper Washer/Sterilizers are designed for the complete treatment of sealing devices for pharmaceutical products, rubber and plastic stoppers, droppers, metal rings, etc.

The LT machines is fully automated, and available in six sized to accommodate a wide variety of customer requirements.  The smallest unit (20L) can process roughly 6,000 of the 20mm standard stoppers, while the largest unit (240L) can process roughly 72,000 of the same.  The complete cycle time for the LST (including sterilization) is approximately 3.5 hours, with a guaranteed residual moisture content up to 0.01%

Characteristics of LT Series Stopper Washer

• Operating process consists of Washing, Rinsing, Siliconizing (oil or emulsion), Drying, and Cooling
• Distribution of load into separate baskets for better results;  by separating the stoppers, there is little or no mass weight to cause interlocking - thereby offering maximum surface exposure during each cycle phase
• Washing is done by simultaneously rotating the basket(s) and fluid-bed action from a recycling pump and spray nozzles.  The particles in suspension are removed
• Even siliconization of products guaranteed by recycling pump
• Sterilization temperature is 121ºC;  temperature deviation does not exceed +/- 0.1ºC during validation
• Drying is done through the use of HEPA filtered air
• Optional interface of unloading door to isolator
• Optional automatic loading and unloading systems
• All materials in contact with the process are 316SS
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant
• Capacity from 20L to 240L

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Equipment/Parts/Glassware Washer

    ICOS has a long history of treatment of parts and glassware normally used in the pharmaceutical industry.  The newest series of washer, the ML Series, has many innovative features that exceed the strict requirements of the pharmaceutical industry's regulatory agencies. 

    The ML washers' operating process consists of pre-washing, washing, rinsing, drying, and cooling phases.  Through these processes, they are designed for the washing, disinfecting and drying of pharmaceutical products.  These products may include glassware, pipettes, machine parts, tanks, glass bottles, pill stamps, carboys, etc.

Characteristics of the ML Washer

• Distribution of load in racks, carts, and baskets for better performance results
• Disinfection by means of dosing different detergents
• Washing and rinsing by simultaneously spraying water through nozzles from a recycling pump, and direct spray of pressurized WFI water - the particles in suspension are skimmed off
• Drying is done through the use of HEPA filtered air (max temp. = 130ºC)
• Optional interface of unloading door to isolator
• Single Door or Pass thru capability
• Variety of racks/carts and baskets allow for a variety of materials to be processed
• All components in contact with the process  are 316/316L w/roughness less than 0.5μm
• Components not in contact with the process fluids are 304SS
• 3º slope on all process piping
• All internal corners of the chamber are rounded for ease of cleaning
• PLC based control system manages the machine and basic parameters such as phase time, pressure, temperature, detergent dosing, water conductivity, PH level, and water level control
• CE & UL mark available;  GAMP4 & cGMP compliant, 21 CFR parts 11, 210 & 211 compliant
• Capacity for the ML series washers range from 343 Liters to 3480 Liters
• Download PDF - ICOS Glassware and Parts Washers

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Tray Drying Ovens

    ICOS manufactures a wide range of drying ovens ranged in two main categories - hot air drying ovens (EG Series) and vacuum drying ovens (EG-V Series).  Hot-air drying ovens remove moisture through the inflow circulation and removal of heated air.  Vacuum drying ovens extract moisture through the creation of a vacuum in the chamber.  Each technique finds different applications, depending on the type of product to be dried.  Ovens range in size from 309L to 7644L and up.

EG Series Characteristics:

• Drying thru Hot Air Recirculation
• Filtration of inlet air flow, and exhaust air flow
• Even distribution of air in the chamber through special diaphragms
• Drying temperature control
• Provided with special product handling shelves, and available for shelf handling carts
• 316/304SS construction
• Heated through steam or electric heating elements
• Fast-closing swing-out doors
• Maximum operating temperature of 120ºC

EG-V Series Characeristics:

• Vacuum drying in chamber
• Filtration of incoming air flow
• Full control of process parameters
• Provided with special product handling shelves, and available for shelf handling carts
• 316/304SS construction
• Heated through steam or electric heating elements
• Fast-closing swing-out doors
• Maximum operating temperature of 100ºC

Options on both EG / EG-V Series

• Optional self-washing system in the chamber
• Device for removal and insertion of the tray support structures available
• For certain product processing, components can be flameproof

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Tank Cleaning Enclosure

    ICOS considerable experience from 20 years of activity in the washing and sterilizing field has brought about the newest range of equipment for the treatment of tanks.  The BL series is a Modular Box that includes washing, rinsing and drying phases; the TLS series is a Tunnel (Box) that includes washing, rinsing, sterilizing, and drying phases.  Capacities range from 5,000L to 33,210L

BL Series Characteristics:

• Automatic internal washing of tank by spray ball, with addition of detergent (as necessary)
• Automatic internal rinsing of tank by spray ball
• External washing by means of relative manual hose
• Internal drying by means of compressed air heated by a heat exchanger
• 304SS Construction
• Front of box has antistatic and self-extinguishing PVC Strips
• Components of hydraulic system are of sanitary type
• Watertight walls
• All Fluid contact piping is polished to a roughness of ≤0.5mm

TLS Series Characteristics

• Automatic internal washing of tank by spray ball, with addition of detergent (as necessary)
• Automatic internal rinsing of tank by spray ball
• Internal sterilization of tank as 121ºC
• Internal drying by means of compressed air heated by a heat exchanger
• Class 100 air inside the tunnel maintained and processed by means of HEPA-type filters, heat exchanger, and a recycling fan
• Constructed for through type processing;  made of 304SS
• Loading & Unloading door of folding type with manual opening w/pneumatic locking devices
• Components of hydraulic system are of sanitary type
• Watertight walls
• All Fluid contact piping is polished to a roughness of ≤0.5mm

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